Wei Wang

EMAIL：oneway1985（at）pku（dot）edu（dot）cn

 

Research Area：

Formation of stress granule is an important post-transcriptional and translational regulatory mechanism. Studies in mammalian cells have associated stress granule with neurodegenerative diseases, cancer cell death, virus infection, immunity and inflammation. However, the function of stress granule in plants is largely unknown. We integrate cell biology, molecular biology, proteomics, genomics and bioinformatics approaches to investigate the formation mechanism, biological function and the evolution significance of stress granule. To facilitate the high throughput and quantitative studies of molecular interactions, we are also involved in the development of novel nanosensor to replace surface plasmon resonance.

 

Selected Publications:

1.    Feng, S., Chen, C., Wang, W.*, Que, L.* An aptamer nanopore-enabled microsensor for detection of theophylline. Biosensors and Bioelectronics (2018), 36-41 (*corresponding author)

2.       Song, C., Chen, C., Che, X., Wang, W., Que, L.* Detection of plant hormone abscisic acid (ABA) using an optical aptamer-based sensor with a microfluidic capillary interface. IEEE 30th International Conference on MEMS (2017), 370-373 (*corresponding author)

3.     Feng, S., Che, X., Que, L.*, Chen, C., Wang, W.* Rapid detection of theophylline using aptamer-based nanopore thin film sensor. Proc. IEEE Sensors Conference (2016), 1658-1660 (*corresponding author)

4.     Zhou, M.*, Wang, W.*, Karapetyan, S., Mwimba, M., Marqués, J., Buchler, N., Dong, X. Redox rhythm reinforces the circadian clock to gate immune response, Nature (2015) 523, 472-476 (*co-first author)

5.     Wang, S.*, Gu, Y.*, Zebell, S.*, Anderson, L., Wang, W., Mohan, R., Dong, X. A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity, Cell Host & Microbe (2014) 16, 787-794 (*co-first author)

6.       Yan, S., Wang, W., Marqués, J., Mohan, R., Saleh, A., Durrant, W., Song, J., Dong, X. Salicylic acid activates DNA damage responses to potentiate immunity in plants, Molecular Cell (2013) 52, 602-610

7.        Fu, Z.*, Yan, S.*, Saleh, A.*, Wang, W., Ruble, J., Oka, N., Mohan, R., Spoel, S., Tada, Y., Zheng, N., Dong, X. NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants, Nature (2012) 486, 228-232 (*co-first author)

8.       Mukhtar, K., Wang, W., Tada, Y., Oka, N., Tucker, C., Fonseca, J., Dong, X. The HSF-like transcription factor, TBF1, is a major molecular switch for growth-to-defense transition in plants, Current Biology (2012) 22, 103-112

9.      Wang, W.*, Barnaby, J.*, Tada, Y., Li, H., Tör, M., Caldelari, D., Lee, D., Fu, X., Dong, X. Timing of plant immune responses by a central circadian regulator, Nature (2011) 470, 110-114 (*co-first author)

10.     Cao, Y., Lou, Y., Han, Y., Shi, J., Wang, Y., Wang, W., Ming, F. Al toxicity leads to enhanced cell division and changed photosynthesis in Oryza rufipogon L, Molecular Biology Reports (2011) 38, 4839-4846

11.     Ming, F.*, Lu, Q.*, Wang, W.*, Zhang, S., Guo, B., Shen, D. Cloning, expression and function of phosphate transporter encoded gene in Oryza sativa L., Science in China Series C: Life Sciences (2006) 49:409-413 (*co-first author)