Zhengfan JIANG
Email: jiangzf(at)pku(dot)edu(dot)cn；
Telephone: +86-10-62757923；
Lab Homepage: http://www.bio.pku.edu.cn/cell/jiangzflab/members.htm
Research Areas:
Innate immunity is the first line of defense against microbial invasions via a set of pattern-recognition molecules. We have established a powerful cDNA library screening system to search systematically for new genes essential in innate immunity. Using Yeast two hybrid screen, immuno-purification and Mass-spec-based protein identification techniques, we are also interested in identifying new genes in the signal complexes. Current projects in the lab focus on 1) Mechanism through which cells recognize dsDNA. 2) Function of ubiquitination in innate immunity. 3) Mechanisms leading to cytokine production and secretion after infection. 4) Malfunction of innate immunity and related diseases.
Selected Publications:
1. Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z*, Activation of STAT6 by STING is Critical for Antiviral Innate Immunity. Cell, 147 (2): 436-446, 2011.
2. Zhou X, You F, Chen H, Jiang Z* , Poly(C)-binding protein 1 mediates house-keeping degradation of mitochondrial antiviral signaling (MAVS). Cell Research, 10.1038/cr.2011.184, 2011.
3. You FP, Sun H, Zhou X, Sun WX, Liang SM, Zhai ZH and Jiang ZF*, PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. NATURE IMMUNOLOGY, 10, 1300-1308, 2009.
4. Sun WX, Li Y, Chen L, Chen HH, You FP, Zhou X, Zhou Y, Zhai ZH, Chen DY, Jiang ZF*, ERIS, an ER IFN stimulator, activates innate immune signaling through dimerization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(21), 8653-8. 2009.
5. Xiao H, Qian W, Staschke K, Qian YC, Cui G, Deng L, Ehsani M, Wang XL, Qian YW, Chen ZJ, Gilmour R, Jiang ZF*, LiXX*, Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kB activation, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 283(21), 14654-64. 2008.
6. Jiang ZF, Georgel P, Li CL, Choe JW, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath SY, Wilson IA, Olson A, Beutler B*, Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(29), 10961-66, 2006.
7. Jiang ZF, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B*, CD14 is required for MyD88-independent LPS signaling, NATURE IMMUNOLOGY, 6(6), 565-70. 2005.