胡泽平
电子邮件：zeping_hu@tsinghua.edu.cn
电话：＋86-10-62799839（实验室）
实验室网页：https://www.sps.tsinghua.edu.cn/info/1011/1427.htm
研究方向：
本实验室长期致力于探索肿瘤、心血管等疾病的代谢重塑规律、功能与调控机制，发现新药靶点，以及研发新型代谢组学/多组学技术。药物新靶点的鉴定是严重制约当前新药研发的关键瓶颈。诸多重大疾病，如癌症、心血管疾病、糖尿病等，都与代谢异常密切相关。因此，深入研究疾病代谢异常的功能与调控机制不仅可以解答重要的基础代谢生物学问题，还有望发现可作为潜在新药靶点的关键通路或节点。
本实验室专注于探索细胞内及组织微环境中不同类型细胞（包括肿瘤、神经、免疫、成纤维细胞等）之间的代谢互作，单细胞代谢异质性，以及这些因素在肿瘤和心血管疾病的发展及耐药性中的功能与调控机制。通过这些研究，我们旨在发掘潜在的治疗靶点和生物标志物，为开发新型精准诊疗策略提供科学基础和依据。我们特别关注神经递质/神经肽等介质在肿瘤微环境中促进肿瘤—神经—免疫细胞间代谢互作和单细胞代谢异质性的作用与调控机制。同时，本实验室也专注于围绕疾病代谢重塑的技术需求，研发新型超灵敏微量代谢组学、单细胞代谢组学技术，以及人工智能（AI）辅助的多组学整合技术。 代表性论文 Research articles（通讯/共同通讯作者）
1. Chen Y#, Wang B#, Zhao Y#, Shao X#, Wang M#, Ma F#, Yang L, Nie M, Jin P, Yao K, Song H, Lou S, Wang H, Yang T, Tian Y*, Han P*, Hu ZP*. Metabolomics machine learning predictor of diagnosis and prognosis of gastric cancer. Nature Communications. 2024;15(1):1657.
2. Fan H#, Xu Z#, Yao K#, Zheng B, Zhang Y, Wang X, Zhang T, Li X, Hu H, Yue B*, Hu ZP*, Zheng H*. Osteoclast cancer cell metabolic cross-talk confers PARP inhibitor resistance in bone metastatic breast cancer. Cancer Research. 2024;84(3):449-467.
被选为同期Featured Article.
3. Nie M#, Chen N#, Pang H#, Jiang T#, Jiang W, Tian P, Yao L, Chen Y, DeBerardinis RJ, Li W, Yu Q, Zhou C, Hu ZP*. Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse. Journal of Clinical Investigation. 2022;132(20):e160152
4. Yuan M#, Tu B#, Li H#, Pang H#, Zhang N, Bai J, Shu Z, Christopher C, Huo S, Zhai J, Yao K, Wang L, Ying H, Zhu WG, Fu D, Hu ZP*, Zhao Y*. Cancer associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth. Nature Cancer. 2022;3(8):945-960.
被Nature Cancer 的News & Views评论 (Tumor Microenvironment: NUFIP1+ stroma keeps PDAC fed, https://www.nature.com/articles/s43018-022-00421-x)
5. Wang W#, Wang J#,*, Yao K#, Wang S#, Nie M, Xu J, Wu G, Lu M, Pei H, Luo X, Li D, Yang T, Li P, Song L*, Hu ZP*. Metabolic characterization of hypertrophic cardiomyopathy in human hearts. Nature Cardiovascular Research. 2022;1(1):445–461
6. Jiang Y*,#, Deng Y#, Pang H#, Ma T, Ye Q, Chen Q, Chen H, Hu ZP*, Qin CF*, Xu Z*. Treatment of SARS-CoV-2 induced pneumonia with NAD+ and NMN in two mouse models. Cell Discovery. 2022;8(1):38.
7. Nie M#, Yao K#, Zhu X#, Chen N, Xiao N, Wang Y, Peng B, Yao LA, Li P, Zhang P*, Hu ZP*. Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma with therapeutic implications. Nature Communications. 2021;12(1):6479.
被Nature Reviews Cancer 选为Research Highlights (Metabolic Transitions, https://www.nature.com/articles/s41568-021-00438-x)
8. Zhao J#, Yao K#, Yu H#, Zhang L#, Xu Y#, Chen L, Sun Z, Zhu Y, Zhang C, Qian Y, Ji S, Pang H, Zhang M, Chen J, Correia C, Weiskittel T, Lin DW, Zhao Y, Chandrasekaran S, Fu X, Zhang D, Fan HY, Xie W, Li H, Hu ZP*, Zhang J*. Metabolic remodeling during early murine embryo development. Nature Metabolism. 2021;3(10):1372-1384.
被选为封面文章(https://www.nature.com/natmetab/volumes/3/issues/10)；被Science选为Editor’s Pick (Translational Metabolism, https://www.science.org/doi/10.1126/science.acx9416)
9. Pang H#, Jiang Y#, Li J#, Wang Y#, Nie M#, Xiao N, Wang S, Song Z, Ji F, Chang Y, Zheng Y, Yao K, Yao L, Li S, Song L*, Lan X*, Xu Z*, Hu ZP*. Aberrant NAD+ metabolism underlies ZIKA virus-induced microcephaly. Nature Metabolism. 2021;3(8):1109-1124.
10. Xiao N#, Nie M#, Pang H#, Wang B#, Hu J#, Meng X, Li K, Ran X, Long Q, Deng H, Chen N, Li S, Tang N*, Huang A*, Hu ZP*. Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications. Nature Communications. 2021;12(1):1618.
11. Meng X#, Pang H#, Sun F, Jin X, Wang B, Yao K, Yao L, Wang L, Hu ZP*. Simultaneous 3-nitrophenylhydrazine derivatization strategy of carbonyl, carboxyl and phosphoryl submetabolome for LC-MS/MS-based targeted metabolomics with improved sensitivity and coverage. Analytical Chemistry. 2021;93(29):10075-10083.
12. Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu ZP*, DeBerardinis RJ*. Inosine monophosphate dehydrogenase dependence in a subset of small cell lung cancers. Cell Metabolism. 2018;28(3):369-382.e5.
13. Li XK#, Lu QB#, Chen WW#, Xu W#, Liu R, Zhang SF, Du J, Li H, Yao K, Zhai D, Zhang PH, Xing B, Cui N, Yang ZD, Yuan C, Zhang XA, Xu Z, Cao WC*, Hu ZP*, Liu W*. Arginine deficiency is involved in thrombocytopenia and immunosuppression in Severe Fever with Thrombocytopenia Syndrome. Science Translational Medicine. 2018;10(459): eaat4162.
被选为封面文章 (https://www.science.org/toc/stm/10/459)
Invited Reviews/Viewpoints（通讯/共同通讯作者）
14. Wang F#, Fu K#, Wang Y, Pan C, Wang X, Liu Z, Yang C, Zheng Y, Li X, Lu Y, To KKW, Xia C, Zhang J, Shi Z, Hu ZP*, Huang M*, Fu L*. Small-molecule agents for cancer immunotherapy. Acta Pharmaceutica Sinica B (APSB). 2024;14(3):905-952. (Invited Review)
15. Thompson CB*, Vousden KH*, Johnson RS*, Koppenol WH*, Sies H*, Lu Z*, Finley LWS*, Frezza C*, Kim J*, Hu ZP*, Bartman CR*. A century of the Warburg effect. Nature Metabolism. 2023;5(11):1840-1843. (Invited Viewpoint)
16. Pang H, Hu ZP*. Metabolomics in drug research and development: advances in technologies and applications. Acta Pharmaceutica Sinica B (APSB). 2023;13(8):3238-3251. (Invited Review)
17. Wang B#, Yao K#, Hu ZP*. Advances in mass spectrometry-based single-cell metabolite analysis. TrAC Trends in Analytical Chemistry. 2023;163:117075. (Invited Review)
18. Liang L, Sun F, Wang H, Hu ZP*. Metabolomics, metabolic flux analysis and cancer pharmacology. Pharmacology & Therapeutics. 2021;224:107827. (Invited Review)
19. Pang H, Jia W*, Hu ZP*. Emerging applications of metabolomics in clinical pharmacology. Clinical Pharmacology & Therapeutics. 2019;106(3):544-556. (Invited Review)